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More importantly, MSR1 expression was upregulated after LPS stimulation in macrophage RAW264.7, accompanied by increased foaming of macrophages and increased levels of inflammatory factor (97, 98)

These findings indicate that global downregulation of Nrf2 targets and other antioxidant genes, and decreased glutathione and NADPH act to impair persister cell lipid peroxidation defense and contribute to a dependence on GPX4 for survival

H., Liu, G.-S., Thompson, E

During sepsis, the gut barrier is disrupted, allowing microbial products (such as endotoxins) to enter the circulatory system, which can directly damage the mitochondrial function of distant organs (including the lungs)

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